Category Archives: Antimicrobial stewardship

Waiting for perfect science on antimicrobial resistance is a dangerous excuse for policy inaction

A discussion paper newly released by the National Academy of Medicine–Antibiotic Resistance in Humans and Animals–marks the 40 year anniversary of the first definitive evidence  that antibiotic usage in livestock results in the direct spread of antibiotic-resistant bacteria to humans. In releasing the report, the authors pull no punches:

Thus, we have known definitively for more than 40 years that antibiotic usage in livestock results in the direct spread of antibWhatIsDrugResistanceiotic-resistant bacteria to humans. The complete failure of our society to address this concern in the United States is profoundly disappointing and alarming to providers who increasingly struggle to care for patients infected with antibiotic-resistant bacteria. Apologists abound. Excuses are rampant. As alluded to by the British report, “more science” is the often-heard refrain. Those who espouse the need for yet further study before action can be taken typically have close links to farms that continue to use antibiotics. Yet we are past the scientific tipping point.

The issue at hand is one of policy. All policy issues are matters of choosing between pros and cons, risks and benefits. Policy makers almost never have a perfect understanding of all variables at play, nor is it necessary for them to have such precision of information to make choices. Waiting for perfect science is not possible either, because science is constantly in a state of evolution of knowledge based on changing research. Thus, we seek here to summarize the state of the problem in human terms and to inform policy makers of the risks and benefits of taking action or not.

CDCinfographicANTIBIORESISTANCEThis report joins the increasingly urgent public calls for global collective policy action to address the threats posed by antimicrobial resistance to worldwide public health. A World Health Organization (WHO) report released April 2014 called for action against the “serious threat” posed by antimicrobial resistance, a threat that is “happening right now in every region of the world and has the potential to affect anyone, of any age, in any country. Antibiotic resistance—when bacteria change so antibiotics no longer work in people who need them to treat infections—is now a major threat to public health.” 

The report is timely as well as urgent. Earlier this year, scientists discovered the first United States cases of a gene that renders infectious bacteria resistant to the “last-resort” antibiotic drug colistin, a Centers for Disease Control and Prevention (CDC) official testified last week during a congressional hearing on the danger posed by “superbugs”.  Although the NAM report focuses on livestock antimicrobial use as a top priority, antimicrobial use in humans is still an important focus, especially in light of a report last month finding that at least 30 percent of antibiotics prescribed to humans in the United States are unnecessary.

 

Medical ecology: tending the microbiome

Today, the Obama administration announces the new National Microbiome Initiative, intended to create scientific tools, discoveries and training techniques related to the human microbiome, the 100 trillion microbes that live in the human body. Tending the human microbiome may help in the treatment of infections, as well as disorders that would seem unrelated to microbes, including obesity and diabetes.

The microbiome represents the only organ that can be replaced without surgery,” said Jo Handelsman, a microbiologist at the White House. “Just by eating differently, taking drugs, exercising and other things, you can have fairly immediate effects on your microbiome and your health, if we only knew how.”

Microbiome research also has important public health implications. New research, for instance, suggests that much of the world’s childhood malnutrition arises not from a lack of food, but from problems with children’s intestinal microbiomes caused by poor sanitation.India-Sanitation-web-Artboard_1