Neither of the two drugs used most frequently to prevent migraines in children–amitriptyline and topiramate–is more effective than a placebo, according to results of the Childhood and Adolescent Migraine Prevention (CHAMP) trial published this week in The New England Journal of Medicine. The investigators found no significant differences in reduction in headache frequency or headache-related disability in childhood and adolescent migraine with amitriptyline, topiramate, or placebo over a period of 24 weeks.
The active drugs were associated with higher rates of adverse events. One child on topiramate attempted suicide. Three taking amitriptyline had mood changes; one told his mother he wanted to hurt himself, while another wrote suicide notes at school and was hospitalized.
Migraine headaches are common in children. Up to 11 percent of 7- to 11-year-olds and 23 percent of 15-year-olds have migraines.
Beautifully written and argued. Most appropriate ! Love, Dad
Sent from my iPhone
LikeLike
Thank you for the read! It was great!
You may find this interesting: CPR and Amiodarone https://medicine-handbook.com/blog/cpr-and-amiodarone/
LikeLike
That is a great post on CPR and the role of early effective CPR vs. medications. I especially liked your perspective on the role of subgroup analyses.
LikeLiked by 1 person
Great
LikeLiked by 1 person